Immunotoxin conjugate which comprises arsanilic acid, useful for

Details Immunotoxin conjugate which comprises arsanilic acid, useful for Immunotoxin conjugate which comprises arsanilic acid, useful for

1982-08-13

1984-11-27

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 260112B, 260112R, A61K 3900, A61K 4502, A23J 000, C07G 700

Patent

active

044850930

ABSTRACT:
An immunotoxin conjugate, useful for treating malignant tumors in mammals, which consists of arsanilic acid and tumor specific antibodies covalently bound to a polyglutamic acid linking agent is taught. The conjugate selectively delivers arsanilic acid to a tumor, killing the tumor cells and exhibiting little or no toxicity to normal cells. The conjugate is effective in treating human pancreatic cancer.

REFERENCES:
patent: 4033819 (1977-07-01), Helting
patent: 4046722 (1977-09-01), Rowland
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4359457 (1982-11-01), Neville, Jr. et al.
patent: 4368149 (1983-01-01), Masuho et al.
patent: 4440747 (1984-04-01), Neville, Jr. et al.

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