Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1986-09-19
1989-09-05
Kight, John
Drug, bio-affecting and body treating compositions
Lymphokine
424 858, 514885, 436547, 530387, 530403, 530806, A61K 39395, A61K 3942, C07K 1506, G01N 33577
Patent
active
048637300
ABSTRACT:
An immunotherapy treatment for a patient infected with the virus giving rise to the acquired immune deficiency syndrome (AIDS) and resulting in a breakdown in the patient's immune response. In this treatment, a supply of plasma is derived from serum-positive individuals who carry the AIDS virus yet are free of the clinical symptons associated with AIDS or with any AIDS-related complex. The plasma supply is processed to provide a preparation rich in antibodies having neutralizing properties in respect to the AIDS virus, the processed plasma being free of red blood cells and other impurities. The processed plasma is transfused intravenously into the infected patient in a dosage which is safe and efficacious, and the transfusion procedure is repeated at spaced intervals of time until the deficiency in the immune response of the patient is substantially overcome.
REFERENCES:
patent: 4617379 (1986-10-01), Dobkin et al.
patent: 4639513 (1987-01-01), Hou et al.
Referee's report from the Proceedings of the National Academy of Sciences, U.S.A., on an article by Karpas, et al., "Effects of Passive Immunization in Patients with the AIDS-related Complex and Acquired Immune Deficiency Syndrome."
Stricker et al., "An AIDS-related Cytotoxic Autoantibody Reacts with a Specific Antigen on Stimulated CD4.sup.+ Cells", Nature, vol. 327, pp. 710-713, Jun. 1987.
Walker et al., "CD8.sup.+ Lymphocytes can Control HIV Infection in Vitro by Suppressing Virus Replication", Science, vol. 234, pp. 1563-1566, Dec. 1986.
Karpas et al., "Lytic Infection by British AIDS Virus and Development of Rapid Cell Test for Antiviral Antibodies", The Lancet, Sep. 28, 1985, pp. 695-697.
Cenfold Holdings S.A.
Kight John
Nutter Nathan M.
Olstein Elliot M.
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