Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-03-18
2000-10-10
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514344, 514345, 514346, 514349, 514350, 514351, 514352, 514354, 546249, 546348, 546286, 546288, 546289, 546290, 546291, 546292, 546304, 546314, 546329, 546345, A61K 31345, A61K 3144, A61P 1106, C07D21180
Patent
active
061302260
ABSTRACT:
Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor .alpha., nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.
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Mamadzhanov A. et al., Condensation of pyrocathecol and its methyl ethers with alpha-phenylbenzyl alcohols in the presence of polyphosphoric acid:, Chemical Abstracts, vol. 94(25), 1981 208463b.
Muller George W.
Shire Mary
Celgene Corporation
McKane Joseph
Oswecki Jane C.
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