Immunotherapeutic agents

Details Immunotherapeutic agents Immunotherapeutic agents

1998-01-14

1999-10-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514411, 546110, 548450, 548451, A61K 3144, A61K 3140, C07D22106, C07D20956

Patent

active

059689455

ABSTRACT:
Novel amides and imides are inhibitors of tumor necrosis factor.alpha. and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. Typical embodiments include 3-(1,3-dioxobenzo[f]isoindol-2-yl)-3-(3-cyclopentyloxy-4-methoxyphenyl)pro pionamide and 3-(1,3-dioxo-4-azaisoindol-2-yl)-3-(3,4-dimethoxyphenyl)-propionarnide.

REFERENCES:
Tiers (Thermochim. Acta (1993), 226 (1-2), 317-24).
David Cavalla, et al., "Phosphodiesterase IV Inhibitors: Structural Diversity and Therapeutic Potential In Asthma", Current Medical Chemistry, 1995, 2, pp. 561-572.
Louis J. Lombardo, "Phosphodiesterase-IV Inhibitors: Novel Therapeutics for the Treatment of Inflammatory Diseases", Current Pharmaceutical Design, 1995, pp. 255-268.
John A. Lowe, III, et al., "The PDE IV family of calcium-independent phosphodiesterase enzymes", Drugs of the Future, 1995, 20(8): 799-807.
Malcolm N. Palfreyman, "Phosphodiesterase type IV Inhibitors as antiflammatory agents", Drugs of the Future, 1995, 20(8): 793-804.
Les Sekut, et al., "Pathophysiology and Regulation of TNF-.alpha. in Inflammation", DN& P, 9(5) Jun. 1996, pp. 261-269.

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