Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1997-08-11
1999-07-27
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514520, 514532, 514538, 514584, 514585, 514613, 514617, 514619, 514622, 514630, 514631, 514646, 514678, 514679, 514764, 514784, 514785, 558401, 558402, 558410, 560 61, 560 64, 560 73, 562405, 562434, 562452, 562455, 562459, 562463, 562465, 562490, 564123, 564161, 564166, 564167, 564182, 568308, 585 24, 585 25, 546348, 5463461, 546579, 549 80, 549429, 5483461, 548579, A61K 31215, A61K 31275, C07C 1504, C07C 1546, C07C 43205, C07C 43215, C07C25533, C07C25534
Patent
active
059291176
ABSTRACT:
Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor .alpha., nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.
REFERENCES:
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Muller George W.
Shire Mary
Celgene Corporation
Oswecki Jane C.
Richter Johann
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