Immunosupressive analogues and derivatives of succinylacetone

Details Immunosupressive analogues and derivatives of succinylacetone Immunosupressive analogues and derivatives of succinylacetone

1989-03-15

1990-01-23

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514547, 514557, 514675, 514578, A61K 3122, A61K 3119, A61K 3112

Patent

active

048958727

ABSTRACT:
Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: ##STR1## and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

REFERENCES:
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patent: 4835185 (1989-05-01), Nisser
Tschudy, D. et al., 1982, Chem. Abstracts, 96:210579d.
Weinback, E. D. et al., 1985, Chem. Abstracts, 103:35547f.
Beaumont, C. et al., 1986, Chem. Abstract, 105:150346t.
Hoult, R. C. et al., 1986, Chem. Abstracts, 105:222421p.
Hamilton, J. W. et al., 1988, Chem. Abstracts, 109:167885y.
Skolik, S. A. et al., 1988, Chem. Abstracts, 109:18322n.

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