Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2010-04-20
2011-12-06
Huynh, Phuong (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S185100, C424S192100, C530S350000, C530S387100, C530S387300, C530S395000
Reexamination Certificate
active
08071095
ABSTRACT:
The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
REFERENCES:
patent: 5116964 (1992-05-01), Capon et al.
patent: 5155027 (1992-10-01), Sledziewski et al.
patent: 5336603 (1994-08-01), Capon et al.
patent: 5428130 (1995-06-01), Capon et al.
patent: 5434131 (1995-07-01), Linsley et al.
patent: 5455165 (1995-10-01), Capon et al.
patent: 5514582 (1996-05-01), Capon et al.
patent: 5565335 (1996-10-01), Capon et al.
patent: 5637481 (1997-06-01), Ledbetter et al.
patent: 5770197 (1998-06-01), Linsley et al.
patent: 5773253 (1998-06-01), Linsley et al.
patent: 5843725 (1998-12-01), Sledziewski et al.
patent: 5844095 (1998-12-01), Linsley et al.
patent: 5851795 (1998-12-01), Linsley et al.
patent: 5885579 (1999-03-01), Linsley et al.
patent: 5885796 (1999-03-01), Linsley et al.
patent: 5916560 (1999-06-01), Larsen et al.
patent: 5993800 (1999-11-01), Linsley et al.
patent: 6018026 (2000-01-01), Sledziewski et al.
patent: 6090914 (2000-07-01), Linsley et al.
patent: 6117655 (2000-09-01), Capon et al.
patent: 6132992 (2000-10-01), Ledbetter et al.
patent: 6291212 (2001-09-01), Sledziewski et al.
patent: 6291646 (2001-09-01), Sledziewski et al.
patent: 6300099 (2001-10-01), Sledziewski et al.
patent: 6323323 (2001-11-01), Sledziewski et al.
patent: 6406697 (2002-06-01), Capon et al.
patent: 6444792 (2002-09-01), Gray et al.
patent: 6482919 (2002-11-01), Ledbetter et al.
patent: 6521419 (2003-02-01), Koduri et al.
patent: 6623940 (2003-09-01), Ledbetter et al.
patent: 6685941 (2004-02-01), Thompson et al.
patent: 6710169 (2004-03-01), Capon et al.
patent: 6750334 (2004-06-01), Gray et al.
patent: 6800457 (2004-10-01), Koduri et al.
patent: 7041634 (2006-05-01), Weber et al.
patent: 7070776 (2006-07-01), Linsley et al.
patent: 7094874 (2006-08-01), Peach et al.
patent: 7105166 (2006-09-01), Linsley et al.
patent: 7307064 (2007-12-01), Rusnak
patent: 7332303 (2008-02-01), Schilling et al.
patent: 7794718 (2010-09-01), Karrer et al.
patent: 2003/0083246 (2003-05-01), Cohen et al.
patent: 2003/0219876 (2003-11-01), Ledbetter et al.
patent: 2004/0022787 (2004-02-01), Cohen et al.
patent: 2004/0151725 (2004-08-01), Gray et al.
patent: 2004/0185046 (2004-09-01), Thompson et al.
patent: 2005/0196402 (2005-09-01), Gray et al.
patent: 2005/0214313 (2005-09-01), Peach et al.
patent: 2008/0070280 (2008-03-01), Schilling
patent: 2008/0160022 (2008-07-01), Larsen
patent: 0314317 (1989-05-01), None
patent: 0325224 (1989-07-01), None
patent: 0610046 (1994-08-01), None
patent: 0613944 (1994-09-01), None
patent: 0757099 (1997-02-01), None
patent: 0832971 (1998-04-01), None
patent: 1666498 (2006-06-01), None
patent: WO8902922 (1989-04-01), None
patent: WO9108298 (1991-06-01), None
patent: WO9300431 (1993-01-01), None
patent: WO9319767 (1993-10-01), None
patent: WO9639514 (1996-12-01), None
patent: WO9711607 (1997-04-01), None
patent: WO9728267 (1997-08-01), None
patent: WO9734633 (1997-09-01), None
patent: WO9947558 (1999-09-01), None
patent: WO0017337 (2000-03-01), None
patent: WO0037504 (2000-06-01), None
patent: WO0192337 (2001-12-01), None
patent: WO0202638 (2002-01-01), None
patent: WO 2005/017148 (2005-02-01), None
patent: WO2006108035 (2006-10-01), None
patent: WO2008047150 (2008-04-01), None
patent: WO 2009/058564 (2009-05-01), None
Brunet JF, et al. A new member of the immunoglobulin superfamily—CTLA-4. Nature 1987; 328(6127):267-270.
Harper K, et al. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J. Immunol. 1991; 147.
Morton PA, et al. Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2). J. Immunol. 1996; 156(3):1047-1054.
Nuttall SD, et al. Design and expression of soluble CTLA-4 variable domain as a scaffold for the display of functional polypeptides. Proteins 1999; 36(2):217-227.
Ostrov DA, et al. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 2000; 290(5492):816-819.
Peach RJ, et al. Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J. Exp. Med. 1994; 180(6):2049-2058.
Schwartz JC, et al. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature 2001; 410 (6828):604-608.
Sorensen P, et al. Identification of protein-protein interfaces implicated in CD8O-CD28 costimulatory signaling. J. Immunol. 2004; 172(11):6803-6809.
Stamper CC, et al. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature 2001; 410(6828):608-611.
Truneh A, et al. Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis. Mol Immunol. 1996; 33(3):321-334.
Vaughan AN, et al. Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7. J. Immunol. 2000; 165 (6):3175-3181.
Villinger F, et al. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Immunogenetics 2001; 53(4):315-328.
Bass Steven H
Chapin Steven J
Karrer Erik E
Neighbors Margaret
Paidhungat Madan M
Fujita Sharon M.
Huynh Phuong
Perseid Therapeutics, LLC
Petithory Joanne R.
Powers Margaret A.
LandOfFree
Immunosuppressive polypeptides and nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunosuppressive polypeptides and nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunosuppressive polypeptides and nucleic acids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4310637