Immunosuppressive glycoprotein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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435 681, 514 8, 530350, 530412, 530417, C07K 300, C07K 1300, C07K 1500, A61K 3710

Patent

active

051091160

ABSTRACT:
The disclosure describes novel immunosuppressive agents isolated from syncytiotrophoblast microvilli membranes by preparing a minutely subdivided and solubilized preparation of said membranes and isolating the unreduced N-linked oligosaccharides from an extract of the preparation.

REFERENCES:
patent: 4977244 (1990-12-01), Muchmore et al.
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Hunziker and Wegmann, CRC Critical Rev. Immunol. 6, 245-285 (1986).
Chaouat and Monnot, Am. J. Reprod. Immunol. 6, 5-8 (1984).
Mowbray et al., Lancet, Apr. 27, 1987, pp. 941-943.
Jenkins et al., Brit. Med. J. 1, 542-544 (1978).
Muchmore & Decker, Science 229, 479-481 (1985).
Muchmore & Decker, J. Immunol. 138, 2541-2546 (1987).
Muchmore et al., J. Immunol. 138, 2547-2553 (1987).
Hession et al., Science, 237, 1479-1484 (1987).
Smith et al, Nature 252, 302-303 (1974).
Pennica et al, Science 236, 83-88 (1987).

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