Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-10-02
2007-10-02
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S258000
Reexamination Certificate
active
10651604
ABSTRACT:
This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, having the formula:wherein X represents an oxygen atom or a group with the formula NZ and wherein: R1C1-7alkyl or arylalkyl; Z is a group independently defined as R1or the group NZ together with R1is an optionally substituted heterocyclic group containing at least one nitrogen atom; R2is amino or acylamino; R4is an atom or a group selected from the group consisting of hydrogen; C1-7alkyl; and C1-7alkoxy; and R3is an atom or a group selected from the group consisting of aryl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-7alkyl, and C1-7alkoxy, their pharmaceutically acceptable salts, and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and being useful in the treatment in transplant rejection, certain inflammatory diseases, cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.
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Herdewijn Piet André Maurits Maria
Pfleiderer Wolfgang Eugen
Waer Mark Jozef Albert
4 Aza Bioscience NV
Clark & Elbing LLP
Rao Deepak
LandOfFree
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