Immunosuppressive effects of 8-substituted xanthine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S264100, C514S265100

Reexamination Certificate

active

09564200

ABSTRACT:
The invention relates to a novel use of 8-substituted xanthine derivatives for the manufacture of a medicament for the treatment of auto-immuno disorders.

REFERENCES:
patent: 4879296 (1989-11-01), Daluge et al.
patent: 5559121 (1996-09-01), Harrison et al.
patent: 0490181 (1992-06-01), None
patent: WO 95/11681 (1995-05-01), None
patent: 9636638 (1996-11-01), None
Katzung, B.G., Basic and Clinical Pharmocology, 6thed., 1995, p. 864-865.
Functionalized Congeners of 1,3-Dialkylxanthines: Preparation of Analogues with High Affinity for Adenosine Receptors; Jacobson et al.; 1985; vol. 28, pp. 1334-1340.
8-Substituted Xanthines as Antagonists at A1- and A2- Adenosine Receptors; Jacobson et al.; 1988; vol. 37, pp. 3653-3661.
Sulfur-Containing 1,3-Dialkylxanthine Derivatives as Selective Antagonists at A1-Adenosine Receptors; Jacobson et al.; 1989; vol. 32, pp. 1873-1879.
Effect of Trifluoromethyl and Other Substituents on Activity of Xanthines at Adenosine Receptors; Jacobson et al.; 1993; vol. 36, pp. 2639-2644.
Effects of 8-Phenyl and 8-Cycloalkyl Substituents on the Activity of Mono-, Di-, and Trisubstituted Alkylxanthines with Substitution at the 1-, 3-, and 7-Positions; Shamim et al.; 1989; vol. 32, pp. 1231-1237.
Synthesis of Paraxanthine Analogs (1,7-Disubstituted Xanthines) and Other Xanthines Unsubstituted at the 3-Position: Structure-Activity Relationships at Adenosine Receptors; Müller et al.; 1993; vol. 36, pp. 3341-3349.
QSAR studies of 8-substituted xanthines as adenosine receptor antagonists; Doichinova et al.; 1994; vol. 29, pp. 133-138.
Use of Methylxanthine Derivative A802715 in Transplantation Immunology; Lin et al.; 1997; vol. 63, pp. 1734-1738.
A1Adenosine Receptor Antagonists as Ligands for Positron Emission Tomography (PET) and Single-Photon Emission Tomography (SPET); Holschbach et al.; 1998; vol. 41, pp. 555-563.
M. Mayne et al., Dysregulation of Adenosine A1Receptor-Mediated Cytokine Expression in Peripheral Blood Mononuclear Cells from Multiple Sclerosis Patients,Ann. Neurol., 1999, pp. 633-639, vol. 45.
G. Hasko et al., Adeonsine: a potential mediator of immunosuppression in multiple organ failure,Current Opinion in Pharmacology, 2002, pp. 440-444, vol. 2, Elsevier Science Ltd.

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