Chemistry: analytical and immunological testing – Biospecific ligand binding assay – Utilizing isolate of tissue or organ as binding agent
Patent
1996-07-26
1998-07-14
Stucker, Jeffrey
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
Utilizing isolate of tissue or organ as binding agent
436518, 435 71, 530328, 530350, 530827, G01N 33567
Patent
active
057803072
ABSTRACT:
Purified immunosuppressive drug binding protein (immunophilin) of molecular weight 34-37 kDa and pI of about 6.5 is described. The 34-37 kDa immunophilin specifically binds FK-506, rapamycin and CsA with high affinity. This novel immunophilin can be used as a reagent for capturing, detecting and quantififying immunosuppressive drugs and their biologically active metabolites, derivatives and analogues in tissue or fluid samples, and for the capturing potential immunosuppressive drugs from microbial extracts or culture media.
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