Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Lignin or derivative doai
Patent
1995-11-13
1998-04-14
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Lignin or derivative doai
514468, 549299, A61K 3134, C07D30777, C07D30792
Patent
active
057391149
ABSTRACT:
Immunosuppressive cyclolignan derivatives are provided of formula (I) or (II): ##STR1## in which R.sup.1 is hydrogen, hydroxy, alkoxy; R.sup.2 and R.sup.3 are hydrogen, alkyl, acyl, or together R.sup.2 and R.sup.3 form a group --CHR.sup.4 --; R.sup.4 is hydrogen, alkyl, alkenyl, hydroxyalkyl, (poly)haloalkyl, aryl, acyloxyalkyl, alkoxy, carboxyalkyl, alkoxycarbonyl, carbamoyl; R.sup.5 when present is hydrogen, alkyl, alkenyl, aryl, (poly)haloalkyl, acyl, carbamoyl, or thiocarbamoyl; R.sup.6 is alkyl, hydroxyalkyl, haloalkyl, acyl, acyloxyalkyl, carboxy or alkoxycarbonyl; Ar is 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; and X is nitrogen or oxygen.
REFERENCES:
patent: 4567253 (1986-01-01), Durst et al.
patent: 4644072 (1987-02-01), Vyas et al.
Hartwell and Schrecker, "The Chemistry of Podophyllum", Progress in the Chemistry of Organic Natural Products, pp. 84-166, 1957.
Terada et al., "Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structural Relationship of Podophyllotoxin Derivatives as Antitumor Agents", Chem. Pharm. Bull., 40(10) 2720-2727, 1992.
Thurston et al., "Antitumor Agents. 78. Inhibition of Human DNA Topoisomerase II by Podophyllotoxin and .alpha.-Peltatin Analogues", J. Med. Chem., 29:1547-1550, 1986.
Hansen et al., "New Compounds Related to Podophyllotoxin and Congeners: Synthesis, Structure Elucidation and Biological Testing". Acta Chemica Scandinavica, vol. 47 (1993), pp. 1190-1200.
Jones et al., "Synthesis of (.+-.)-4-Deoxypodophyllotoxin, (.+-.)-Podophyllotoxin and (.+-.)-Epipodophyllotoxin", Journal of the Chemical Society, Perkin Transactions 1, Nov., 1993, pp. 2541-2548.
Buchardt et al., "Thermal Chemistry of Podophyllotoxin in Ethanol and a Comparison of the Cytostatic Activity of the Thermolysis Products", Journal of Pharmaceutical Sciences, vol. 75, No. 11, Nov. 1986, pp. 1076-1080.
Forsey et al., "Comprehensive Synthetic Route to Eight Diastereomeric Podophyllum Lignans", The Journal of Organic Chemistry, vol. 54, No. 18, 1 Sep. 1989, pp. 4280-4290.
Gordaliza et al., "Antineoplastic and antiviral activities of podophyllotoxin related lignans", Chemical Abstracts, vol. 120, No. 19, Abstract No. 120: 235425c. (May 9, 1994).
Gordaliza et al., "Antineoplastic and Antiviral Activities of Podophyllotoxin Related Lignans,", Arch Pharm., vol. 327, No. 3, 1994, pp. 175-179.
Terada et al., "Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structure Relationship of Podophyllotoxin Derivatives as Antitumor Agents", Chemical & Pharmaceutical Bulletin, vol. 40, No. 10, Oct. 1992, pp. 2720-2727.
Thurston et al., "Antitumor Agents. 100. Inhibition of Human DNA Topoisomerase II by Cytotoxic Ether and Ester Derivatives of Podophyllotoxin and .alpha.-Peltatin", Journal of Medical Chemistry, vol. 32, No. 3, Mar. 1986, pp. 604-608.
Castro Maria Angeles
del Corral Jose Maria Miguel
Faircloth Glynn T.
Gordaliza Marina
Lopez Maria Luisa
Linek Ernest V.
Oswecki Jane C.
Richter Johann
Universidad de Salamanca
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