Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-07-02
1994-07-19
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514423, 514428, 514885, A61K 31445, A61K 3140
Patent
active
053309936
ABSTRACT:
This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamass) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.
REFERENCES:
Harding et al, Nature 341:758-760 (1989), "A Receptor for the Immunosuppressant FK506 is a cis-trans Peptidyl-prolyl Isomerase".
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Armistead David M.
Boger Joshua S.
Meyers Harold V.
Saunders Jeffrey O.
Tung Roger D.
Hook Gregory
Vertex Pharmaceuticals Inc.
Waddell Frederick E.
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