Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-07-02
1993-03-09
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514330, 514428, 546226, 546245, 548533, C07D21132, C07D21104, C07D26708
Patent
active
051927730
ABSTRACT:
This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamase) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.
REFERENCES:
D. R. Williams et al., Synthesis of the .alpha.,.beta.-Diketo Amide Segment of the Novel Immuno Suppressive FK506, J. Org. Chem., vol. 53, No. 19, 1988.
Egbertson et al., J. Org. Chem. 54:11-12 (1989).
Coleman et al., Heterocycles 28:157-61 (1989).
Finberg et al., Science, 249:287-291 (Jul. 20, 1990).
Kaczmar et al., Makromol. Chem. 177:1981-9 (1976).
Blaschke et al., Chemical Abstracts, 85:78405k (Sep. 20, 1976).
Effenberger et al., Chemical Abstracts 110:154847h.
J. Chem. Soc. Chem. Commun. 15:1016-17 (1984).
J. Chem. Soc. Perkin Trans. I 4:769-772 (1985).
Bull. Soc. Cim. Fr. 2:185-91 (1989).
Armistead David A.
Boger Joshua S.
Meyers Harold V.
Saunders Jeffrey O.
Tung Roger D.
Ivy C. Warren
Twardzik Barbara
Vertex Pharmaceuticals Inc.
LandOfFree
Immunosuppressive compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunosuppressive compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunosuppressive compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-211733