Immunosuppressive compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 11, 514278, A01N 4338, A01N 4342, A61K 3800

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active

060515961

ABSTRACT:
A pharmaceutical composition containing a non-specific (NS) suppressor cell inducing compound and cyclosporin A and a pharmaceutically acceptable carrier or diluent, and method of inducing an immunosuppressive effect in a mammal, including a hyman, in need thereof which comprises administering an effective dose of a non-specific suppressor cell inducing compound and cyclosporin A to such mammal.

REFERENCES:
patent: 4963557 (1990-10-01), Badger et al.
Journal of Pharmacology and Experimental et al., Therapeutics, vol. 2 #1, Oct. 3 1985, DiMartino et al., "Antiarthritic and Immunoregulatory Activity of Spieogermanium" pp. 103-110.
Immunopharacology, vol. 10, 1985 Badger et al., "Generation of Suppressor Cells in Normal Rats by Treatment with Spirogermanium,A Novel Heterocyclic Anticancer Drug" pp.201-200.
Chemical Abstracts, vol. 110, No 69098V, issued Feb.27, 1989. Yoshimura et al., "Effect of the new immunosuppressive agent FK 506 on lymphokine production and responsiveness of human peripheral blood lymphocytes", See page 26, Column 4, abstract 690980 Igaku no Ayumi 1988, vol. 147 (a), 783-4 (Japan).
Chemical Abstracts, vol. 87, No. 15, issued Oct. 10, 1977, Martel et al., "Inhibition of the immune response by rapamycin, a new antifungal antibiotic", See p. 90, Column 1,abstract #111825p, Can. J. Physiol Pharmacol 1977, vol. 55 (1), vol. 55 (1) 48-51.
Chemical Abstracts, Col. 95, No. 21, issued Nov. 23, 1981, Bunjes et al., "Cyclosporin A mediates immunosuppression of primary cycotoxic T cell response by imparing the release of interleukin 1 and interleukin 2", p. 28, column 1 abstract #180735, Eur. J.Immunol. 1981, vol. 11 (8).

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