Immunosuppressive-1-(thiocarbamoyl)-2-imidazolidinone

Details Immunosuppressive-1-(thiocarbamoyl)-2-imidazolidinone Immunosuppressive-1-(thiocarbamoyl)-2-imidazolidinone

1978-03-06

1979-09-18

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424 99, A61K 31415

Patent

active

041683161

ABSTRACT:
By isolation and purification from the urine of patients treated with niridazole there is obtained substantially pure 1-(thiocarbamoyl)-2-imidazolidinone which exhibits marked immunosuppressive activity. A particular isolation procedure is described in addition to a chemical synthesis as follows: ##STR1##

REFERENCES:
chemical Abstracts, vol. 86:150570a; 1977 citing Lucas et al., J. Immunol. 1977, 118 (2), pp. 418-422.
Daniels et al., The Journal of Immunology, vol. 115, No. 5, Nov. 1975, pp. 1414-1421.
Helv. Chem. Acta., vol. 49, pp. 2443-2452 (1966).
The Condensed Chem. Dictionary, 6th Ed., p. 395, Reinhold Pub. Corp., N.Y., May 4, 1964.

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