Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1992-03-09
1993-04-13
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
436827, C12N 120, C12R 1045
Patent
active
052022587
ABSTRACT:
Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934, and "demethimmunomycin" (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 4981792 (1991-01-01), Inamine et al.
Arai, T., et al. (1962) J. Antibiotics 15, 231-232.
Arison Byron H.
Chen Shieh-Shung T.
Garrity George M.
Inamine Edward S.
Mochales Sagrario
Caruso Charles M.
Merck & Co. , Inc.
North Robert J.
Patterson Jr. Charles L.
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