Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-03-08
1997-10-21
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 15, 514 13, A61K 3800, A61K 3802, C07K 500, C07K 700
Patent
active
056796404
ABSTRACT:
Peptide compositions are provided which bind MHC molecules of interest and inhibit T cell activation. The peptide compositions of the present invention comprise various isosteres of naturally occurring amino acid sequences. Such compositions may be used to treat diseases associated with particular DR alleles, including autoimmune diseases such as rheumatoid arthritis.
REFERENCES:
patent: 4826765 (1989-05-01), Greene et al.
Urban et al., Cell, vol. 59, pp. 257-271, 1989.
Wraith et al., Cell, vol. 59, pp. 247-255, 1989.
Mazerolles et al., Cell, vol. 55, pp. 497-504, Nov. 1988.
Urban, J.L., et al., Autoimmune T Cells: "Immune Recognition of Normal and Variant Peptide Epitopes and Peptide-Based Therapy", Cell, 59:257-271 (1989).
Wraith, D.C., et al., "Antigen Recognition in Autoimmune encephalomyelitis and the Potential for Peptide-Mediated Immunotherapy", Cell, 59:247-255 (1989).
PCT/US90/00085 (WO 90/08161) 6 Jul. 1990.
Arrhenius Thomas S.
Gaeta Federico C. A.
Grey Howard M.
Powell Michael F.
Sette Alessandro D.
Cytel Corporation
Davenport Avis M.
Sandoz Ltd.
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