Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1988-06-29
1991-01-01
Bond, Robert T.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435117, 435118, 435128, 435193, 4352526, 435827, 540456, 514183, 514321, C12P 1716, C01D49816, A61K 31395
Patent
active
049817922
ABSTRACT:
Described is a process for producing a new immunosuppressant, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934 under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in prevent human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 3244592 (1966-04-01), Arai
J. Antibiotics 15, p. 231-232 (1962) by T. Arai et al.
Derwent Abstract-Japanese Kokai J6 3017-884-A (English), May 30, 1986.
Arison Byron H.
Chen Shieh-Shung T.
Inamine Edward S.
Wicker Linda S.
Bond Robert T.
Merck & Co. , Inc.
North Robert J.
Pfeiffer Hesna J.
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