Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-06-16
1994-03-01
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
435117, 435118, 435128, 435193, 435169, 540456, 540457, A61K 3133
Patent
active
052907724
ABSTRACT:
Described is a process for producing an immunosuppressant, "demethimmunomycin" (L-683,7411) a C-31 demethylated analog of L-683,590 under fermentation conditions utilizing the microorganism, Actinoplanacete sp, (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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patent: 3244592 (1966-05-01), Arai
patent: 4981792 (1991-01-01), Dnamine et al.
Torikata et al., J. Antihiotics, vol. 36(8), pp. 957-975.
Goodfellow, Biology of Actionomycetes, 1984, pp. 59-103 & 350-357.
Krauch et al., Organic Name Reactions, 1964, p. 484.
Arison Byron H.
Chen Shieh-Shung T.
Inamine Edward S.
Wicker Linda S.
Griffin Ronald W.
Merck & Co. , Inc.
North Robert J.
Pfeiffer Hesna J.
Thies J. Eric
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