Immunosuppressant

Details Immunosuppressant Immunosuppressant

1994-02-17

1997-06-17

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241301, 4241411, 4241451, 514 8, 5303873, 53038823, C07K 1646, A61K 39395

Patent

active

056394551

ABSTRACT:
Peptides which inhibit the binding of human IL-6 to human IL-6 receptor are useful as a treatment for diseases induced or aggravated by IL-6. DNA fragments, vectors, transformants, and methods useful for preparing such peptides are described.

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Nature, vol. 347, pp. 497-498, Oct. 4, 1990, A. Pluckthun, "Antibodies From Escherichia coli".
The Journal of Biological Chemistry, vol. 266, No. 25, Sep. 5, 1991, Yves Laroche, et al., "Characterization of a Recombinant Single-Chain Molecule Comprising the Variable Domains of a Monoclonal Antibody Specific for Human Fibrin fragment D-Dimer", pp. 16343-16349.
Molecular Immunology, vol. 28, No. 11, pp. 1155-1161, Nov., 1991, Toshiro Shimamura, et al. "Analysis of Interleukin 6 (IL-60/IL-6 Receptor System Using Monoclonal Anti-IL-6-Antibodies".

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