Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-05-02
2006-05-02
Housel, James (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C424S184100
Reexamination Certificate
active
07038029
ABSTRACT:
Oligonucleotides containing the non-palindromic sequence motif:in-line-formulae description="In-line Formulae" end="lead"?X1X2X3X4X5X6X7X8,in-line-formulae description="In-line Formulae" end="tail"?wherein X1is C,T,G or A (preferably T or C); wherein X2is C,T,G or A; wherein X7is C,T,G or A (preferably G); at least three, and preferably all, of X3, X4, X5, X6and X8are T; and with the proviso that, in the motif, a C does not precede a G (in other terms, the nucleic acid motif does not consist of a CpG oligonucleotide), that modulate the immune response of animals of the order Primate, including humans, are disclosed. This immune modulation is characterized by stimulation of proliferation, differentiation, cytokine production and antibody production on B-cells and cell differentiation on plasmacytoid dendritic cells.
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Angier, N., “
Chen Stacy B.
Darby & Darby
Housel James
Immunotech S.A.
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