Immunostimulatory agents

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4242781, 530321, A61K 3812, A61K 4505

Patent

active

056398522

ABSTRACT:
Compositions and methods are described for the synthesis of novel analogs of cyclosporin A, and the use of those analogs as immunostimulatory agents.

REFERENCES:
patent: 4384996 (1983-05-01), Bollinger et al.
patent: 4771122 (1988-09-01), Seebach
patent: 4814323 (1989-03-01), Andrieu et al.
patent: 4914188 (1990-04-01), Dumont et al.
patent: 5284826 (1994-02-01), Eberle et al.
N.A. Campbell in Biology (3rd. ed.), Benjamin Cummings Publishing Company, Inc., Redwood City, CA, pp. 850-872 (1993).
L.L. Lanier, "Distribution and Function of Lymphocyte Surface Antigens," Ann. N.Y. Acad. Sci., 677:86-93 (1993).
S.B. Mizel et al., "Characterization of Lymphocyte-Activating Factor (LAF) Produced by a Macrophage Cell Line, P388D.sub.1, II. Biochemical Characterization of LAF Induced by Activated T Cells and LPS," J. Immunol., 120:1504-1508 (1978).
J. Shaw et al., "Effects of Costimulator on Immune Responses in vitro," J. Immunol., 120:1974-1980 (1978).
H.S. Teh et al., "Direct Evidence for a Two-Signal Mechanism of Cytotoxic T-Lymphocyte Activation," Nature 285:163-165 (1980).
J. Shaw et al., "Cellular Origins of Co-Stimulator (IL2) and Its Activity in Cytotoxic T Lymphocyte Responses," J. Immunol., 124:2231-2239 (1980).
S. Chouaib, "Tumor Necrosis Factor .alpha.: a Costimulator for Cytotoxic Cell Differentiation," Nouv. Rev. Fr. Hematol., 33:471-475 (1991).
M.K. Jenkins et al., "CD28 Delivers a Costimulatory Signal Involved in Antigen-Specific IL-2 Production by Human T Cells," J. Immunol., 147:2461-2644 (1991).
J.D. Fraser et al., "Regulation of T-Cell Lymphokine Gene Transcription by the Accessory Molecule CD28," Mol. Cell Biol., 12:4357-4363 (1991).
L. Koulova et al., "The CD28 Ligand B7/BB1 Provides Costimulatory Signal for Alloactivation of CD4.sup.+ T Cells," J. Exp. Med., 173:759-762 (1991).
J.A. Gross et al, "Identification and Distribution of the Costimulatory Receptor CD28 in the Mouse," J. Immunol., 149:380-388 (1992).
C.P. Larsen et al., "Functional Expression of the Costimulatory Molecule, B7/BB1, on Murine Dendritic Cell Populations," J. Exp. Med., 176:1215-1220 (1992).
John E. Kay, "Inhibitory Effects of Cyclosporin A on Lymphocyte Activation" in Cyclosporin, Mode of Action and Clinical Application, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 1-19 (A.W. Thomson, ed.) (1989).
J.F. Borel, "Cyclosporine: Historical Perspectives" in Cyclosporine, Biological Activity and Clinical Applications, Grune and Stratton, Inc., Orlando, Fl, pp. 3-12, Wenger/Lafferty 26-31 (B.D. Kahan, ed.) (1984).
J.F. Borel, "The History of Cyclosporin A and Its Significance" in Cyclosporin A, Elsevier Biomedical Press, Amsterdam, The Netherlands, pp. 5-15, (D.J.G. White, ed.) (1982).
D.H. Rich et al., "Synthesis and Antimitogenic Activities of Four Analogues of Cyclosporin A Modified in the 1-Position," J. Med. Chem., 29:978-984 (1986).
W.J. Colucci et al., "Synthesis of D-Lysine.sup.8 -Cyclosporine A. Further Characterization of BOP-C1 in the 2-7 Hexapeptide Fragment Synthesis," J. Org. Chem., 55:2895-2903 (1990).
R.D. Tung et al., "BOP-C1 Mediated Synthesis of the Cyclosporine A 8-11 Tetrapeptide Fragment," J. Org. Chem., 51:3350-3354 (1986).
R.M. Wenger, "Total Synthesis of 'Cyclosporin A' and 'Cyclosporin H', Two Fungal Metabolites Isolated from the Species Tolypocladium Inflatum GAMS," Helv. Chim. Acta 67:502-524 (1984).
J. Coste et al., "Oxybenzotriazole Free Peptide Coupling Reagents for N-Methylated Amino Acids," Tetrahedron Lett., 32:1967-1970 (1991).
E. Gross in The Peptides: Analysis, Synthesis, Biology (vol. 1), Academic Press, Inc., New York, NY, p. 332 (1979) one page.
U. Schollkopf, "Recent Applications of .alpha.-Metalated Isocyanides in Organic Synthesis," Angew. Chem., 16:339-422 (1977).
D.A. Evans et al., "Asymmetric Glycine Enolate Aldol Reactions: Synthesis of Cyclosporine's Unusual Amino Acid, MeBmt," J. Am. Chem. Soc., 108:6757-6761 (1986).
M.A. Gallop et al., "Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries," J. Med. Chem., 37:1233-1248 (1994).
E.M. Gordon et al., "Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions," J. Med. Chem., 37:1385-1399 (1994).
A. Karpas et al., "Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506," Proc. Natl. Acad. Sci., 89:8351-8355 (1992).
C. Damasco et al., "Cyclosporin A inhibits vaccinia virus replication in vitro," Arch. Virol., 134:303-319 (1994).
L. Carpino, "1-Hydroxy-7-azabenzotriazole. An Efficient Peptide Coupling Additive," J. Am. Chem. Soc., 115:4397-4398 (1992).
T. Novak et al., "Interleukin-1 Synergy with Phosphoinositide Pathway Agonists for Induction of Interleukin-2 Gene Expression: Molecular Basis of Costimulation," Mol. Cell. Biol., 10:6325-6334 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Immunostimulatory agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunostimulatory agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunostimulatory agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2158718

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.