Immunostimulating guanosine derivatives and their pharmaceutical

Details Immunostimulating guanosine derivatives and their pharmaceutical Immunostimulating guanosine derivatives and their pharmaceutical

1988-05-05

1992-03-03

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 24, A61K 3170, C07H 19167

Patent

active

050933183

ABSTRACT:
7,8-Disubstituted guanosine nucleoside derivatives are found to be potent immune response enhancing agents in human and animal cells. 7-Substituents are heteroatom-substituted-hydrocarbyl radicals having a length greater than ethyl and less than about decyl. 8-Substituents are .dbd.O, .dbd.S, .dbd.Se and .dbd.NCN. Compositions and methods of use are also disclosed.

REFERENCES:
patent: 4539205 (1985-09-01), Goodman et al.
patent: 4948730 (1990-08-01), Goodman et al.
Smee, D., et al., Antimicrobial Agents and Chemotherapy, vol. 33, pp. 1487-1492, 1989.
Nagahara, K., et al., J. Med. Chem., vol. 33, pp. 407-415, 1990.

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