Immunostimulating guanine derivatives, compositions and methods

Details Immunostimulating guanine derivatives, compositions and methods Immunostimulating guanine derivatives, compositions and methods

1991-04-29

1992-08-04

Rollin, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 2100

Patent

active

051360306

ABSTRACT:
7,8-Disubstituted quanosine nucleoside derivatives are found to be potent immune response enhancing agents in human and animal cells. 7-Substituents are hydrocarbyl radicals having a length greater than ethyl and less than about decyl. 8-Substituents are .dbd.O, .dbd.S, .dbd.Se and .dbd.NCN. Compositions and methods of use are also disclosed.

REFERENCES:
Chem. Abs., 72:55806j (1970).
Chem. Abs., 106:16903q (1987).
Come et al., Tetrahedron Lett., 32:4823-4826 (1991).
Come et all, J. Chinese Chem. Soc. (Taiwan) (Preprint) Aug., 1991).

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