Immunostimulating and immunopotentiating reconstituted influenza

Details Immunostimulating and immunopotentiating reconstituted influenza Immunostimulating and immunopotentiating reconstituted influenza

1994-04-11

1999-03-09

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242781, 4242811, 4242831, 424450, 424 89, 424 88, A61K 3929, A61K 4500, A61K 4744

Patent

active

058796851

ABSTRACT:
Immunostimulating reconstituted influenza virosomes (IRIVs) are provided wherein an antigen or a combination of antigens are incorporated into a virosome further containing a mixture of phospholipids, an essentially reconstituted functional virus envelope, and influenza hemagglutinin protein (HA). The HA induces fusion of the IRIV with cellular membranes and thereby induces lysis of the IRIV after its endocytosis by antigen presenting cells.

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