Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fl

Details Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fl Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fl

1991-11-27

1993-10-05

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

536 2855, 514 50, A61K 3702, A61K 4505

Patent

active

052502961

ABSTRACT:
Disclosed is an immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine or a salt thereof in combination, which shows a strong therapeutic effect by synergistic action and weak side effects. The immunostimulant agent may further contain another chemotherapeutic agent and/or another immunotherapeutic agent.

REFERENCES:
patent: 4518584 (1985-05-01), Mark et al.
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Fujita et al Gan to Kagaku Ryoho 14(5 pt 1) pp. 1297-1304, (May 1987) (Abstract only).
Corbett et al Cancer vol. 40, No. 5 Nov. 1977, pp. 2660-2680.
Japanese Journal of Cancer and Chemotherapy, vol. 13, No. 4, 1986 plus English translation.
Japanese Journal of Cancer and Chemotherapy vol. 12, No. 9, 1985, plus English translation.
G. Mills et al. Generation of Cytotoxid Lymphocytes to Syngeneic Tumors by Using Do-Stimulator Interluekin 2: In Vivo Activity, J. Immunology, vol. 125 p. 1904 (1980).
S. Rosenberg et al., A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interluekin-2 Alone, N.E. J. of Medicine, vol. 316 pp. 889-897 (1987).
A. Cook et al, Fluorinated Pyrimidine Nucleosides. 3..sup.1 Synthesis and Antitumor Activity of a Series of 5'-Deoxy-5-fluropyrimidine Nucleosides, J. of Medicinal Chem., vol. 22, pp. 1330-1335 (1979).
Y. Ninomiya et al, Cancer and Chemotherapy, 15 (5), 1747-1754. (Abstract only).

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