Immunostimulant agent, compositions thereof and methods for thei

Details Immunostimulant agent, compositions thereof and methods for thei Immunostimulant agent, compositions thereof and methods for thei

1975-05-02

1978-02-28

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3902, A61K 3904

Patent

active

040768015

ABSTRACT:
The immunostimulant agent is extracted from splenic cells of animal origin from Ehrlich ascites cells or from bacteria, such as Bacillus subtilis or Saccharomyces cerevisiae. A suspension of these cells or of these bacteria is formed with a mixture of solvents containing a halogenated hydrocarbon and an alcohol. The insoluble fractions are separated, the liquid fraction evaporated under reduced pressure and at reduced temperature, and the solid residue taken up again in chloroform. The chloroform solution containing the abovementioned immunostimulant agent is recovered by filtration. A suspension in an injectable liquid vehicle of the immunostimulant agent is in the form of particles or micelles whose dimensions are sufficiently small for said suspension to be injectable in man or animal.

REFERENCES:
patent: 3089821 (1963-05-01), Folkers
patent: 3185624 (1965-05-01), Nakazawa

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