Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-11-08
2010-10-26
Kolker, Daniel E. (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07820398
ABSTRACT:
Immunosorbents, kits and compositions for diagnosing a central nervous system disorder, particularly paroxysmal cerebral discharges and epilepsy, comprising measuring the concentration of GluR1 or fragment thereof and/or GluR1 antibodies in a biological sample from a human subject. The method is particularly useful for identifying individuals that are at risk for brain related seizures and epilepsy, for distinguishing epilepsy from pseudo-epilepsy and epilepsy-like disorders, for following up after anticonvulsive treatment, and for the adjustment of adequate therapy and doses.
REFERENCES:
patent: 4879289 (1989-11-01), Zobrist et al.
patent: 5739291 (1998-04-01), Heinemann et al.
patent: 6896872 (2005-05-01), Dambinova
patent: 2005/0233390 (2005-10-01), Allen
patent: 2006/0024749 (2006-02-01), Dambinova
patent: 2006/0172341 (2006-08-01), Dambinova
patent: 2006/0172342 (2006-08-01), Dambinova
patent: 2006/0257943 (2006-11-01), Dambinova
patent: 0558747 (1993-09-01), None
patent: 2112243 (1998-05-01), None
patent: WO 93/00586 (1993-01-01), None
patent: WO 94/06345 (1994-03-01), None
Producing Polyclonal Antibodies. (downloaded Sep. 14, 2006) Gallus immunotech, inc. pp. 1-2.
Nath et al. (2000). Neurochem int. 37, 351-61. Abstract only.
Williamson et al (1992). Ann. Neurol. 31, 3-13. Abstract only.
Sviridova et al. (1990) Zh. Nevrapato Psikhiatr. Im S S Korsakova. 90, 3-5. Abstract only.
Radhadrishnan et al. (1981). Clin Neurol. Neurosurg. 83, 87-94. abstract only.
Stigbrand et al. (2000). Int J. Biol. Markers 15, 33-40. Abstract only.
Morozov et al. (1996). Zh. Nevrapato Psikhiatr. Im S S Korsakova. 96, 71-74. Abstract only.
Dambinova et al (1998). J. Neurochem. 71, 2088-2093.
Dambinova et al. (1997) J. neurochem. 152, 93-97.
Hornbeck (1991. Current Protocols in Molecular Biology 11.2.1 - 11.2.22).
Andrews, P.I., and McNamara, J.O., “Rasmussen's encephalitis: an autoimmune disorder?,”Curr. Opin. Neurol., 9(2):141-145 (Apr. 1996).
Andrews, P.I., et al., “Plasmapheresis in Rasmussen's encephalitis,”Neurology, 46(1):242-246 (Jan. 1996).
Bellinger, D.C., et al., “Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass,”Circulation, 100(5):526-532 (Aug. 3, 1999).
Besedin, V.I., et al., “Molecular organization of glutamate-sensitive chemoexcitable membranes of nerve cells. Function of glutamate-binding proteins of the central nervous system when incorporated into liposomes”,Chem. Abstr., 102:198497h (1985) (abstract of Russian-languageBiokhimiia, 50(3):363-368 (Mar. 1985)).
Bi, X., et al., “Characterization of calpain-mediated proteolysis of GluR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors in rat brain,”J. Neurochem., 68(4):1484-1494 (Apr. 1997).
Bi, X., et al., “The C-terminal domain of glutamate receptor subunit 1 is a target for calpain-mediated proteolysis,”Neuroscience, 73(4):903-906 (Aug. 1996).
Boulter, J., et al., “Molecular cloning and functional expression of glutamate receptor subunit genes.,”Science, 249(4972):1033-1037 (Aug. 31, 1990).
Cleary, P., et al., “Late-onset seizures as a predictor of subsequent stroke,”Lancet363(9416):1184-1186 (Apr. 10, 2004).
Dambinova, S.A. et al., “Molecular organization of glutamate-sensitive chemoexcitatory membranes of nerve cells. Comparative analysis of glutamate-binding membrane proteins from the cerebral cortex of rats and humans,”,Chem. Abstr., 108:51550k (1988) (abstract of Russian-languageBiokhimiia, 52(10):1642-1648 (Oct. 1987)).
Dambinova, S.A., and Gorodinskii, A.I., “Molecular organization of the glutamate-sensitive chemoexcitatory membranes of nerve cells. L-[3H]Glutamate binding to synaptic membranes from the rat cerebral cortex,”Chem. Abstr., 100:133097s (1984) (abstract of Russian-languageBiokhimiia, 49(1):67-74 (Jan. 1984)).
Dambinova, S.A., and Izykenova, G.A., “Autoantibodies to subtypes of glutamate receptors as a hallmarks [sic] of brain damage: diagnostic significance for paroxysmal activity and ischemia”,J. Higher Nervous Activity [Zh. Vyssh. Nerv. Deiat. Im. I.P. Pavlova], 47(2):151-156 [439-446 in original Russian version] (Mar.-Apr. 1987).
Dambinova, S.A., et a/., “Molecular organization of glutamate-sensitive, chemoexcitatory membranes of nerve cells. Physicochemical characteristics of the glutamate-binding chemoexcitatory membrane proteins from rat cerebral cortex synamptic membranes”,Chem. Abstr., 100:152673t (1984) (Abstract of Russian-languageBiokhimiia, 49(2):216-221 (Feb. 1984)).
Dambinova, S.A., et al., “Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke,”Clin. Chem., 49(10):1752-1762 (2003).
Dambinova, S.A., et a, “Immunochemical electron microscopic study of glutamate receptor localization in cultured cells of theRattus rattusbrain sensorimotor cortex using monoclonal antibodies,”Chem. Abstr., 111:71506r (1989) (abstract of Russian-languageBiol. Membr., 6:498-506 (1989)).
Dambinova, S.A., et a/., “Immunosorbent for diagnosis of epilepsy and risk group,”Chem. Abstr., 118:100345q (1993) (abstract of Russian-language patent publication WO 93/00586 by Dambinova et al. and Dies Co., Ltd, published Jan. 7, 1993).
Dingledine, R., “The glutamate receptor ion channels,” et al.,Pharmacol. Rev., 51(1):7-61 (Mar. 1999).
Dingledine, R., and McBain, C.J., “Glutamate and Aspartate,” Chap. 15 inBasic Neurochemistry: Molecular, Cellular and Medical Aspects, 6thed, Siegel, G.J., et al., Eds., Philadelphia, Pa.: Lippincott-Raven; (1999), 315-333.
Doherty, J., and Dingledine, R., “Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus,”J. Neurosci., 21(6):2048-2057 (Mar. 15, 2001).
During, M.J., et al., “An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy,”Science, 287(5457):1453-1460 (Feb. 25, 2000).
Fagan, A.M., and Gage, F.H., “Mechanisms of sprouting in the adult central nervous system: cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus,”Neuroscience, 58(4):705-725 (Feb. 1994).
Fletcher, E.J., et al., “Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4,”Receptors Channels3(1):21-31 (1995).
Friedman, L.K., et al., “Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study,”J. Neurosci, 14(5 Pt 1):2697-2707 (May 1994).
Gahring, L.C., et al., “Autoantibodies to neuronal glutamate receptors in patients with paraneoplastic neurodegenerative syndrome enhance receptor activation,”Mol. Med, 1(3):245-253 (Mar. 1995).
Gingrich, M.B., and Traynelis, S.F., “Serine proteases and brain damage—is there a link?”Trends Neurosci., 23(9):399-407 (Sep. 2000).
Grigorenko, E., “Changes in glutamate receptor subunit composition in hippocampus and cortex in patients with refractory epilepsy,” et al.,J. NeuroL Sci., 153(1):35-45 (Dec. 9, 1997).
Huppertz, H.-G.,et al., “Myoclonus in epilepsy patients with anticonvulsive add-oon therapy with pregablalin,”Epilepsia, 42(6):790-792 (2001), provided as abstract.
Kopeloff, L.M., et al., “Recurrent convulsive seizures in animals produced by immunologic and chemical means,”Am. J. Psychiatry, 98:881-902 (1942).
Maslova, O.I. et al., “[Paroxysmal activity test in pediatric neurology],”Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, 98(1):33-36 (1998) (in Russian); provided as English-language abstract.
Meldrum, B.S., “Glutamate as a neurotransmitter in the brain: review of physiology and pathology,”J. Nutr., 130(4S Suppl.):1007S-1015S (Apr. 2000).
Ni
Dambinova Svetlana A.
Izykenova Galina
Arnall Golden & Gregory LLP
Grace Laboratories Inc.
Kolker Daniel E.
Sullivan Clark G.
LandOfFree
Immunosorbent blood tests for assessing paroxysmal cerebral... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunosorbent blood tests for assessing paroxysmal cerebral..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunosorbent blood tests for assessing paroxysmal cerebral... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4239322