Immunoregulatory compounds and derivatives and methods of...

Details Immunoregulatory compounds and derivatives and methods of... Immunoregulatory compounds and derivatives and methods of...

2006-12-19

2006-12-19

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Acyclic nitrogen double bonded to acyclic nitrogen, acyclic...

C514S150000, C514S613000, C514S646000, C534S573000, C564S123000, C564S244000

Reexamination Certificate

active

07151095

ABSTRACT:
Compounds are disclosed having the structure of Formula I:where R1, R3, and R4are independently hydrogen or C1to C4alkyl, and R2is:where R5is selected from the group consisting of hydrogen and C1to C4alkyl, orwhere R6, R7and R8are independently hydrogen or C1to C4alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract.Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed:where R9, R10and R11are independently selected from the group consisting of hydrogen and C1to C4alkyl, and R12is selected from the group consisting of hydrogen and —C(O)R13, where R13is a C1to C6alkyl or an aryl group.

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