Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-11-09
1989-12-12
Rosen, Sam
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142222, 5142225, 514250, 514183, A61K 3155, A61K 3150
Patent
active
048867969
ABSTRACT:
A method of treating autoimmune diseases by suppressing the immune response of an animal is characterized by administering to the animal a compound of the general formula (1): ##STR1## wherein R.sup.0 and R.sup.1 are radicals selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy and acyloxy: R.sup.2 and R.sup.3 are radicals separately selected from the group consisting of hydrogen and alkyl; or together, represent a radical of the general formula (2): ##STR2## wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are radicals separately selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, sulfate, and halogen: or R.sup.2 and R.sup.3 together, represent a radical of the general formula (3): ##STR3## wherein R.sup.10 and R.sup.11 both represent hydrogen; or together, represent a valence bond: R.sup.12, R.sup.13, R.sup.14, R.sup.15 are radicals selected from the group consisting of hydrogen, hydroxy, alkoxy, sulfate and acyloxy; and n is an integer selected from the range 2 to 4; alone or in association with one or more pharmaceutically acceptable carrier or diluents.
REFERENCES:
Murdock et al., Chem. Abst., vol. 72 (1970) p. 90345e.
Murdock--Chem. Abst., vol. 82 (1975) p. 25661x.
Munday--Chem. Abst., vol. 98 (1983) p. 84629w.
Thompson et al.--Chem. Abst., vol. 99 (1983) p. 83484d.
Eichner Ronald D.
Mullbacher Arno
Australian National University
Rosen Sam
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