Immunoreactive heterochain antibodies

Details Immunoreactive heterochain antibodies Immunoreactive heterochain antibodies

1987-11-23

1990-12-18

Warren, Charles F.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

4352402, 4353171, 435 691, 435 701, 43524026, 43524027, C07K 1300

Patent

active

049787454

ABSTRACT:
Immunoreactive heterochain antibodies are described. The heterochain antibodies are made up of light chain and heavy chain variable regions derived from different antibodies. The heterochain antibodies can exhibit antigen binding properties which are different from the parent antibodies from which they are derived. Methods of producing the heterochain antibodies and methods of their use in diagnostic and therapy are also disclosed.

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Neuberger et al., published PCT application Mar. 1986 PCT/GB85/00392.
M. Shulman, et al., Nature, 276: 269-270 (1978).
T. Springer, et al., European Journal of Immunology, 8: 539-551 (1978).
L. K. Sun, et al., Proceedings of the National Academy of Science, U.S.A., 84: 214-218 (Jan. 1987).

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