Immunoprophylactic polypeptides for schistosomiasis

Details Immunoprophylactic polypeptides for schistosomiasis Immunoprophylactic polypeptides for schistosomiasis

1988-09-30

1991-09-24

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

530350, 530387, 530402, A61K 39395, C07K 1300

Patent

active

050512544

ABSTRACT:
Polypeptide epitopes are defined herein which when used as components of vaccine compositions, induced partial immunity to Schistosoma mansoni. The epitopes are found on the surface of schistosomula. The epitopes are part of larger proteins which are immunologically cross-reactive with myosin heavy chains from other species. However, anti-myosin antibodies directed against myosin molecules of other species are not cross-reactive with the surface epitopes of S. mansoni.

REFERENCES:
Strand et al., (1987) Identification and Cloning of S. Mansoni Shistosomolar Surface Antigens Detected by Protective Antibodies. J. Cell. Biochem. Suppl. IIA, 152.
Grzych, Nature, vol. 316, pp. 74-76, 1985.
Capron, Molecular Paradigms for the Eradication of Helminthic Parasites, J. Cell, Biochem., Suppl. 11A, 1987, p. 151, Abstract C024.
Oligino, Molecular Paradigms for the Eradication of Helminthic Parasites J. Cell, Biochem., Suppl. 11A, 1987, p. 151, Abstract C025.
Dissous, Molec. and Biochem., Parasitology, vol. 16, pp. 277-288, (1985).
Kelly, Parasite Immunology, vol. 8, pp. 193-198.
Smithers, Acta Tropica, vol. 44, Suppl. 12, pp. 21-30, (1987).
Lanar, Science, vol. 234, pp. 593-596, (1986).
Newport, Molec. and Biochem. Parasitology, vol. 26, pp. 29-38, (1987).
Second Conference on the Molecular Biology of Schistosomes.
Calton, J. Immunology, vol. 139, pp. 2474-2481 (1987).
Dalton, Experimental Parasitology, vol. 63, pp. 215-226, (1987).
Tom, "Cloning of cDNAs Encoding Schistosomula Antigens," in Molecular Paradigms for Eradicating Helminthic Parasites, A. J. MacInnis, ed., 105-118, Alan R. Liss, N.Y. (1987).

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