Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1988-09-21
1991-10-08
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514885, A61K 3578
Patent
active
050552970
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to an immunopotentiator for patients infected with viruses of an acquired immune deficiency syndrome.
BACKGROUND ART
The acquired immune deficiency syndrome (AIDS) is a disease which is caused by infection with viruses of an immune deficiency syndrome and characterized by a serious cellular immune deficiency. Because a radical cure has not been established for this disease, and further, the high mortality rate thereof, a serious social problem has developed.
At present, as a therapeutic agent for acquired immune deficiency syndrome, there are mentioned antivirus agents such as azide thymidine or the like, immune activators such as interleukin-2, interferon-.gamma. or the like, but these agents do not have decisive therapeutic effects, and therefore, the development of a therapeutic agent for the treatment of acquired immune deficiency syndrome is strongly desired.
DISCLOSURE OF THE INVENTION
The object of the present invention is to provide an immunopotentiator for patients with viruses of an acquired immune deficiency syndrome for the treatment of the acquired immune deficiency syndrome.
The present inventors have conducted research into the immune activating effect of a variety of formulations of Chinese medicines on patients infected with viruses of an acquired immune deficiency syndrome. As a result, the inventors found that Sho-saiko-to (Xiao-Chai-Hu-Tang), which is a formulation of Chinese medicine comprising Bupleuri Radix (root from the plant Bulpeurum falcatum Linne), Scutellariae Radix (root from the plant Scutellaria baicalensis Georgi, from which the periderm has been removed), Glycyrrhizae Radix (root and stolon of the plant Glycyrrhiza uralensis Fisher, Glycyrrhiza glabra Linne or other species of the Glycyrrhiza genus), Ginseng Radix (root from the plant Panax ginseng C. A. Mayer, from which rootlets have been removed, or which has been quickly passed through hot water), Zingiberis Rhizoma (rhizome from the plant Zingiber officinale Roscoe), Zizyphi Fructus (fruit from the plant Zizphus jujuba Miller var. inermis; Rehder or other allied plants) and Pinelliae Tuber (Tuber from the plant Pinellia ternate Breitenbach, from which the cork layer has been removed) and Ninzin-to (Ren-Shen-Tang), which is another formulation of a Chinese medicine comprising Glycyrrhizae Radix, Zingiberis Siccatum Rhizoma (dried rhizome from the plant Zinber officinale Roscoe), Atractylodis Rhizoma (rhizome from the plant Atractylodes ovata De Candolle or its varieties) and Ginseng Radix, have immune activating effects on patients with viruses of acquired immune deficiency syndrome. The present invention is based on this knowledge and is an immunopotentiator which contains Sho-saiko-to (Xiao-Chai-Hu-Tang) or Ninzin-to (Ren-Shen-Tang), for patients infected with acquired immune deficiency syndrome
BEST MODE FOR CARRYING OUT THE INVENTION
Sho-saiko-to (Xiao-Chai-Hu-Tang) is disclosed in the classic references of formulations of Chinese medicine as Shokanron (Shang-Han-Lun) and Kinkiyoryaku (Jin-Kui-Yao-Lue) in which the constituting crude drugs, amounts, extraction methods and the like thereof are described, and is applied to various diseases such as disorders of hepatic function, defect of recovery from post-parturition, or the like. Moreover, it has been already known in the art that it has an immune activating effect on patients with cancer or the like. Similarly, Ninzin-to (Ren-Shen-Tang) is also disclosed in the aforementioned classic references of formulations of Chinese medicine as Shokanron or Kinkiyoryaku, in which the constructing crude drugs, amounts, extraction methods and the like thereof are described, and is applied to various diseases such as acute or chronic enterogastric catarrh, gastroatonia, gastric dilation, hyperemesis, nephroscherosis and the like. However, it has not been hitherto known that Sho-saiko-to (Xiao-Chai-Hu-Tang) and Ninzin-to (Ren-Shen-Tang) have effects on activating the immune function of patients with acquired immune deficien
REFERENCES:
patent: 4469685 (1984-09-01), Kojima et al.
Japanese Document Dated Jun. 10, 1982, pp. 25-27.
Fujimaki Michio
Fukue Hidetaka
Fukutake Katsuhiro
Hada Masao
Ikematsu Shojiro
Juntendo Tsumura
Rollins John W.
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