Immunonodulating compositions and their use

Details Immunonodulating compositions and their use Immunonodulating compositions and their use

1989-11-13

1991-05-28

Doll, John

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 92, A61K 3900, A61K 39002, A61K 3902, A61K 3912

Patent

active

050193848

ABSTRACT:
Novel methods or compositions are provided for modulating the immune system, so as to be able to selectively stimulate or inactivate lymphocytes in relation to a particular transplantation antigen content. Particularly, mixtures may be employed associated with the more common transplanatation antigens of a host population. In this manner, a large number of people can be treated, for example, by immunization, stimulation of particular T-cells or B-cells in relation to a pathogenic invasion of other aberrant state, e.g. neoplasia, treatment of autoimmune diseases, and the like. Particularly, the compositions may involve an oligopeptide involving as a first region a consensus sequence and an epitope or the first region may be joined to a second region comprising an antibody target sequence which is capable of competing with an epitopic site of an antigen of interest.

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