Immunomodulatory protein cloned from ganoderma microsporum

Details Immunomodulatory protein cloned from ganoderma microsporum Immunomodulatory protein cloned from ganoderma microsporum

2006-03-02

2009-10-13

Ramirez, Delia M (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S371000

Reexamination Certificate

active

07601808

ABSTRACT:
An immunomodulatory protein is cloned fromGanoderma microsporum. Its molecular weight is 15863.79 Da. Its genome sequence and translated protein sequence are different from those protected by the known patent of glycoprotein LZ-8, which is isolated from the mycelium ofG. lucidumand has immunomodulator effect, and its immunomodulator efficiency is better than that of LZ-8.

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patent: 2009/0042776 (2009-02-01), Ko et al.
patent: 288959 (1994-12-01), None
Abaza et al., Effects of amino acid substitutions outside an antigenic site on protein binding to monoclonal antibodies of predetermined specificity obtained by peptide immunization: demonstration with region 94-100 (antigenic site 3) of myoglobin, Journal of Protein Chemistry, vol. 11, No. 5, pp. 433-444, 1992.
Coleman, Effects of amino acid sequence changes on antibody-antigen interactions, 55th Forum in immunology : a structural view of immune recognition by antibodies, pp. 33-36, 1994.
Pan et al., Purification and characterization of manganese superoxide dismutase from Ganoderma microsporum, Biochemistry and Molecular Biology International, vol. 42, No. 5, 1997, pp: 1035-1043.
Shizuko Tanaka, Kerry Ko, Kohsuke Kinot, Kazuko Tsuchiya, Akio Yamashita, Akira Murasugi, Sadatoshi Sakuma, and Hajime Tsunoo, “Complete Amino Acid Sequence of an Immunomodulatory Protein, Ling Zhi-8 (LZ-8)”, The Journal of Biology Chemistry, vol. 264, No. 28, pp. 16372-16377, 1989.
Shu-Mei Pan, Jr-Shin Ye, and Ruey-Shyang Hseu, “Purification and Characterization of Manganese Superoxide Dismutase From Ganoderma Microsporum”, Biochemistry and Molecular Biology International, vol. 42, No. 5, pp. 1035-1043, 1997.

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