Immunomodulatory compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S232800, C514S253030, C514S293000, C514S405000, C540S524000, C544S126000, C546S082000, C548S359500

Reexamination Certificate

active

11442548

ABSTRACT:
The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.

REFERENCES:
patent: 4268516 (1981-05-01), Lombardino et al.
patent: 4312870 (1982-01-01), Yokoyama
patent: 4758427 (1988-07-01), Leeson
patent: 6642249 (2003-11-01), Bjork et al.
patent: 91/11448 (1991-08-01), None
patent: 91/12255 (1991-08-01), None
patent: 97/34893 (1997-09-01), None
patent: 03/004495 (2003-01-01), None
L. Savini et al., “High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones”, Bioorganic & Medicinal Chemistry, vol. 9, No. 2, Feb. 2001, pp. 431-444.
V. Colotta et al., Tricyclic Heteroaromatic Systems: Synthesis, [3H] Flunitrazepam Brain Membrane Binding Inhibition, and Structure-Activity Relationships of 2,3-Dihydro-2-aryl-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones, Journal of Pharmaceutical Sciences, vol. 78, No. 3, Mar. 1989, pp. 239-242.
European Search Report dated Jun. 15, 2007.
International Search Report dated Feb. 5, 2004.
David v. Erbe et al., “Small Molecule Ligands Define a Binding Site on the Immune Regulatory Protein B7.1”, J. Biol. Chem., vol. 277, Issue 9, 7363-7368, Mar. 1, 2002.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Immunomodulatory compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunomodulatory compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunomodulatory compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3828883

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.