Immunomodulatory compounds

Details Immunomodulatory compounds Immunomodulatory compounds

2006-07-25

2006-07-25

Powers, Fiona T. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S232800, C514S253030, C514S293000, C514S405000, C540S524000, C544S126000, C546S082000, C548S359500

Reexamination Certificate

active

07081456

ABSTRACT:
The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.

REFERENCES:
patent: 4312870 (1982-01-01), Yokoyama
patent: 6642249 (2003-11-01), Bjork et al.
patent: 91/11448 (1991-08-01), None
patent: 97/34893 (1997-09-01), None
patent: 03/004495 (2003-01-01), None
International Search Report dated Feb. 5, 2004.
David V. Erbe et al., “Small Molecule Ligands Define a Binding Site on the Immune Regulatory Protein B7.1*”, J. Biol. Chem., vol. 277, Issue 9, 7363-7368, Mar. 1, 2002.

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