Immunomodulators and methods for the prevention and reversal of

Details Immunomodulators and methods for the prevention and reversal of Immunomodulators and methods for the prevention and reversal of

1995-04-18

2000-02-15

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241531, 4241561, 4241431, 5303887, 53038873, 53038875, 53038885, C07K 1628, A61K 39395

Patent

active

060249579

ABSTRACT:
Compounds and methods are described for the differential inhibition of tyrosine phosphorylation of phospholipase C-.gamma.1 for the prevention or reversal of transplant rejection as well as therapy for autoimmune diseases. Methods for the treating or preventing tissue or organ transplant rejection and methods for treating an autoimmune disease comprising the administration of monoclonal antibodies that specifically bind to the CD45RB epitope of the CD45RB isoform are disclosed.

REFERENCES:
patent: 4582797 (1986-04-01), Trowbridge
patent: 5565491 (1996-10-01), Schieven

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