Immunomodulators and method of making same

Details Immunomodulators and method of making same Immunomodulators and method of making same

1987-03-16

1989-10-03

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562448, 560312, 549426, C07C10130

Patent

active

048718700

ABSTRACT:
A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is an amino acid identifying group; B is a hydrogen atom, an alkyl group having 1-5, inclusive, carbon atoms, or an aralkyl group having 6-12, inclusive, carbon atoms; carbon atom 2 is of the R configuration; and carbon atom 3 is of the R configuration. The compounds of the invention are effective in augmenting immunological responses and are useful therefore in the treatment of diseases such as cancer, viral infections, bacterial infections, and arthritis.

REFERENCES:
patent: 4552866 (1985-11-01), Delaney et al.
Nishizawa et al., J. of Antibiotics, 36:695 (6/83).
European Patent Application, No. 2,037,754 (7/16/80).
Nahm et al., Tetrahedron Letters, 22:3815 (1981).
Rich et al., Abstract, "Mechanism of Inhibition of Aminopeptidases by Bestatin and Related Analogs".

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