Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1987-03-02
1989-05-30
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 3119
Patent
active
048351857
ABSTRACT:
The commercial performance of domestic animals is improved by feeding keto-isocaproate (KIC) in a form nutritionally utilizable by the animals. The KIC enhances blastogenesis of the animal's T-lymphocytes and reduces plasma cortisol levels. The result is a favorable effect on the immune function of the animal, and can be used to counteract stress-associated immunosuppression. The method is applicable to beef cattle, dairy cattle, sheep, goats, swine, and poultry, as raised, respectively, for meat, milk, wood, or egg production. Practical benefits may also include increased rates of gain and reduced cholesterol in meats and eggs, and increased milk, wool, and egg yields.
REFERENCES:
patent: 4100161 (1978-07-01), Walser
patent: 4100293 (1978-07-01), Walser
patent: 4677121 (1987-06-01), Walser et al.
Sapir et al., (1977), Metabolism, 26:301-308.
Walser, (1983), New Aspects of Clinical Nutrition, pp. 319-324, "Nitrogen-Sparing Effects of Branched Chain Ketoacids", (Karger, Basel).
Boebel et al., (1982), J. Nutr., 112:1929-1939.
Abras et al., (1982), Kidney International, 22:392-397.
Walser, (1984), Clinical Science, 66:1-15, Editorial Review, "Therapeutic Aspects of Branched-Chain Amino and Keto Acids".
Chawla et al., (1975), J. Nutr., 105:788-80.
Chow and Walser, (1974), J. Nutr., 104:1208-1214.
Iowa State University & Research Foundation, Inc.
Waddell Frederick E.
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