Immunomodulation with novel pharmaceutical compositions

Details Immunomodulation with novel pharmaceutical compositions Immunomodulation with novel pharmaceutical compositions

2008-06-17

2008-06-17

Davis, Brian J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S454000, C564S461000, C564S511000, C564S512000, C548S557000, C548S558000, C546S244000, C514S315000, C514S329000, C514S426000, C514S673000, C514S674000

Reexamination Certificate

active

07388112

ABSTRACT:
The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures:wherein a, b and c are integers from 0 to 12, X equals NH or CHNH2, R1and R2each is a hydrogen or a C1to C20aliphatic; aliphatic amine; an alicyclic; aromatic; heterocycle; and halogenated forms thereof; andwherein, a, b and c are integers from 0 to 12; R1, R2, R3, and R4each is a hydrogen or a C1to C20; aliphatic amine; an alicyclic; aromatic; a heterocycle; and halogenated forms thereof.

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Database Inst [Online], INIST Diffusion S.A.; Hasko et al: “Spermine differentially regulates the production of interleukin-12 p40 and interleukin- 10 and supresses the release of the T helper 1 cytokine interferon-gamma”, XP002450725 retrieved from HTTP://CAT.INIST.FR/?AMODELE=AFFICHEN&CPSI DT=1450762 abstract & Hasko et al.: Shock vol. 14, No. 2, 2000, pp. 144-149, Augusta, GA USA.
Zhang et al.: “Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: A counterregulatory mechanism that restrains the immune response”, J. Exp. Med., vol. 185, No. 10, 1997, pp. 1759-1768, XP002450711 USA the whole document.

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