Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2005-12-27
2005-12-27
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C435S007230, C435S007240
Reexamination Certificate
active
06979447
ABSTRACT:
The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.
REFERENCES:
patent: 5104858 (1992-04-01), Hait et al.
patent: 5190931 (1993-03-01), Inouye
patent: 5658955 (1997-08-01), Hitzig
patent: 5703088 (1997-12-01), Sharpe et al.
patent: 6004490 (1999-12-01), Tsai
patent: 2004/0029860 (2004-02-01), Gil-Ad et al.
patent: 2004/0072824 (2004-04-01), Telerman et al.
patent: 2004/0132719 (2004-07-01), Finer et al.
patent: 2005/0013853 (2005-01-01), Gil-Ad et al.
patent: 92/04014 (1992-03-01), None
patent: WO 92/07065 (1992-04-01), None
patent: WO 99/43319 (1999-09-01), None
Stryer et al, in Biochemistry, Third edition, W H Freeman Company, New York, pp. 31-33, 1998.
Ngo et al, 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Attwood et al, The Babel of Bioinformatics, 2000, Science vol. 290 No. 5491: 471-473.
Skolnick et al, From genes to protein structure and function: novel applications of computational approaches in the genomic era, Jan., 2000, TIBTECH 18: 34-39.
Serafeim et al, Blood 99(7): 2545-2553, Apr. 1, 2002.
Oksenberg et al, Nature 360(6400): 161-3, Nov. 1992.
Alberati-Giani et al., 1998, Amino Acids 14:251-255.
Ameisen et al., 1989, J. Immunol. 142:3171-3179.
Aune et al., 1990, J. Immunol. 145:1826-1831.
Aune et al., 1993, J. Immunol. 151:1175-1183.
Aune et al., 1994, J. Immunol. 153:489-498.
Balaian et al., 2000, Eur. J. Immunol. 30:938-943.
Barnes et al., 1999, NeuroPharm. 38:1083-1152.
Boess et al., 1994, Neuropharmacology 33:275-317.
Breeveld, 2000, Lancet 355:735-740.
Bromley et al., 2001, Ann. Rev. Immunol. 19:375-396.
Colcher et al., 1998, Q. J. Nucl. Med. 42:225-241.
Coligan et al., 1999, In: Current Protocols in Immunology, Section 3.1.3-3.1.5.
Coligan et al., 1999, Current Protocols in Immunology, Section 14.1.3-14.1.6.
Cowen, 1991, British J. Psych., 159:7-14.
De Vivo et al., 1986, J. Pharmacol. Exp. Ther. 238:248-252.
Diehl et al., 2000, J. Molec. Med. 78:363-366.
Dutton et al., 1998, Ann. Rev. Immunol. 16:201-223.
Ensminger et al., 2000, Transplantation 69:2609-2612.
Foon et al., 1976, J. Immunol. 117:1545-1552.
Forbes et al., 1993, J. Med. Chem. 36:1104-1107.
Forbes et al., 1996, J. Med. Chem. 39:4966-4977.
Freundlich et al., 1997, Meth. Enzymol. 283:159-173.
Frumento et al., 2001, Transplant. Proc. 33:428-430.
Gershon et al., 1975, J. Exp. Med. 142:732-747.
Graca et al., 2000, J. Immunol. 165: 4783-4786.
Hampel et al., 1989, Biochemistry 28:4929-4933.
Hasselhoff et al., 1988, Nature 334:585-591.
Hillegass et al., 1999, Am. Heart J. 138:S24-S32.
Honey et al., 1999, J. Immunol. 163: 4805-4810.
Kenyon et al., 1999, Proc. Natl. Acad. Sci. USA. 96:8132-8136.
Khan et al., 1986, Int. Arch. Allergy Appl. Immunol. 81:378-380.
Khan et al., 2001, Science 292:1681-1686.
Kinney et al., 2002, Am. J. Public Health 92:24-26.
Kirk et al., 1999, Nature Medicine 5:686-693.
Kohm et al., 2000, Immunology Today 21:539-542.
Kut et al., 1992, Immunopharmacol. Immunotoxicol. 14:783-796.
Laberge et al. 1996, J. Immunol. 156:310-315.
Lucki, 1992, Neurosci. & Biobehav. Rev., 16:83-93.
Marazziti et al. 2001, Neuropsychobiology 43:123-126.
Markees et al., 1998, J. Clin. Invest. 101: 2446-2452.
Mellor et al., 2001, Nature Immunol. 2:64-68.
Meyniel et al., 1997, Immunol. Lett. 55:151-160.
Mossner et al., 1998, Brain, Behavior, and Immunity 12:249-271.
Munn et al. 1998, Science 281:1191-1193.
Munn et al., 1999, J. Exp. Med. 189:1363-1373.
Pan et al., 2000, Transpl. Immunol. 8:189-194.
Price et al., 1997, Naunyn-Schmiedeberg's Arch. Pharmacol. 356:312-320.
Pulendran et al. 1999, Proc. Natl. Acad. Sci. USA 96:1036-1041.
Roszman et al., 1984, Soc. Neurosci. 10:726.
Ruat et al., 1993, Biochem. Biophys. Res. Commun. 193:268-276.
Ruat et al., 1993, Proc. Natl. Acad. Sci. USA 90:8547-8551.
Saha et al., 2001, Neuroimmunomodulation 9:23-33.
Santambrogio et al., 1993, J. Neuroimmunol. 45:113-120.
Siegel et al. 1998, Proc. Natl. Acad. Sci. USA 95:162-166.
Slauson et al., 1984, Cell. Immunol. 84:240-252.
Stefulj et al., 2000, Brain, Behavior, and Immunity 14:219-224.
Tretiakova et al., 2000, Nature Biotechnology 18:984-988.
Weintraub, 1990, Scientific American 262:40-46.
Widner et al., 2000, Immunol. Today 20:469-473.
Wills-Karp, 1999, Annu. Rev. Immunol. 17:255-281.
Young et al., 1993, Immunology 80:395-400.
Schleuning et al., 1994, “Inhibition of cyclosporine A/FK 506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives”, Naunyn-Schmiedeberg's Arch. Pharmacol., 350:100-103.
Travis et al. 1998, British Journal of Psychiatry, 173:236-241.
Albert Ross
Davidson Harold Carter
Jameson Bradford A.
Tretiakova Anna A.
Chan Christina
Drinker Riddle & Reath LLP
Huynh Phuong
Philadelphia Health and Education Corporation
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