Immunomodulation

Details Immunomodulation Immunomodulation

1986-09-10

1989-02-07

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

514 2, 514 12, A61K 4502, A61K 3702

Patent

active

048030724

ABSTRACT:
An immunomodulating pharmaceutical composition comprising an effective, leukocyte interferon production inducing amount of NS1 and a pharmaceutically acceptable carrier or diluent; and a method of modulating the immune response in a human or other animal in need thereof by inducing the production of leukocyte IFN which comprises administering an effective amount of NS1 to such human or animal.

REFERENCES:
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Harfast et al., Scand. J. Immunol., 11, 391 (1985).
Alsheikhly et al., Scan. J. Immunol., 17, 129 (1983).
Arora et al., J. Virology, 52, 389 (1984).
Ali et al., Immunol., 52, 687 (1984).
Djeu et al., J. Exp. Med., 156:1222 (1982).
Starr et al., Infection and Immunity, 30:17 (1980).
Shaw et al., J. Exp. Med., 156, 243 (1982).
Morrongiello et al., Intervirology, 8, 281.
Young et al., "The Origin of Pandemic Influenza Viruses", W. G. Laver, editor, Elsevier Science Publishing Co., Inc. (1983), 129-137.
Young et al, Proc. Natl. Acad. Sci., U.S.A., 80, 6105-6109 (1983).
Shaw et al., Infection and Immunity, 34(3), 1065-1067.
Tiensiwakul et al., Intervirology, 20, 52-55 (1983).

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