Immunomodulating heterocyclic compounds

Details Immunomodulating heterocyclic compounds Immunomodulating heterocyclic compounds

2007-10-02

2007-10-02

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S247000, C544S234000

Reexamination Certificate

active

10547448

ABSTRACT:
Compounds of formula (I) are inhibitors of CD80 and useful in immunomodulation therapy: wherein R1and R3independently represent H; F; CI; Br; —NO2; —CN; C1-C6alkyl optionally substituted by F or Cl; or C1-C6alkoxy optionally substituted by F; R4represents a carboxylic acid group (—COOH) or an ester thereof, or —C(═O)NR6R7, —NR7C(═O)R6, —NR7C(═O)OR6, —NHC(═O)NR7R6or —NHC(═S)NR7R6wherein R6represents H, or a radical of formula -(Alk)m-Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C1-C12alkylene, or C2-C12alkenylene, or C2-C12alkynylene radical or a divalent C3-C12carbocyclic radical, any of which radicals may contain one or more —O—, —S— or —N(R8)— links wherein R8, represents H or C1-C4alkyl, C3-C4alkenyl, C3-C4alkynyl, or C3-C6cycloalkyl, and Q represents H; —NR9R10wherein R9and R10independently represents H; C1-C4alkyl; C3-C4alkenyl; C3-C4alkynyl; C3-C6cycloalkyl; an ester group; an optionally substituted carbocyclic or heterocyclic group; or R9and R10form a ring when taken together with the nitrogen to which they are attached, which ring is optionally substituted; and R7represents H or C1-C6alkyl; or when taken together with the atom or atoms to which they are attached R6and R7form an optionally substituted monocyclic heterocyclic ring having 5, 6 or 7 ring atoms; and X represents a bond or a divalent radical of formula -(Z)n-(Alk)- or -(Alk)-(Z)n-wherein Z represents —O—, —S— or —NH—, Alk is as defined in relation to R6, and n is 0 or 1

REFERENCES:
patent: 4591589 (1986-05-01), Gasc et al.
patent: WO 03/004495 (2003-01-01), None
Salomon, Benoit, et al., B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes, Immunity, vol. 12, 431-440, Apr. 2000.
West, Anthony R.Solid State Chemistry and its Applications, Wiley, New York © 1988, p. 365.

Affiliated with

Also associated with

Rating

Immunomodulating heterocyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunomodulating heterocyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunomodulating heterocyclic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3830248