Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-03-14
2006-03-14
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S193100, C530S300000, C530S350000, C530S395000, C530S403000, C530S868000
Reexamination Certificate
active
07011834
ABSTRACT:
Peptide-like compounds and their variants having immunomodulating activity including the N-terminal acylated and/or C-terminal amidated or esterified forms thereof of up to 60 amino acids wherein the peptide-type compound comprises the formula:in-line-formulae description="In-line Formulae" end="lead"?α−βin-line-formulae description="In-line Formulae" end="tail"?wherein:α and β are the same or different and are of the formula:in-line-formulae description="In-line Formulae" end="lead"?{R aa76-77L}(aa79-84)(SEQ ID NO:1) (a)in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?orin-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?(aa84-79){L aa77-76R}(SEQ ID NO:2) (b)in-line-formulae description="In-line Formulae" end="tail"?wherein:aa76is E or V;aa77is D, S or N;aa79is R or G;aa80is I or N;aa81is a hydrophobic or small amino acid;aa82is R or L;aa83is G or R;aa84is a hydrophobic or small amino acid;whereinthe sequence in the brackets may optionally be absent or truncated at any peptide type bond within the brackets may be used by themselves or in combination with immunosuppressant drugs, to reduce CTL activation, particularly in association with transplantation.
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Buelow Roland
Clayberger Carol
Krensky Alan M.
Chan Christina
DiBrino Marianne
Morrison & Foerster / LLP
The Board of Trustees of Leland Stanford Junior University
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