Immunomodulating and antiinflammatory agent

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241331, 514 2, 514 21, 514826, 514885, 514887, A61K 3514, A61K 3516

Patent

active

057800260

ABSTRACT:
In the present invention, pharmaceutical compositions containing a histamine-added gamma-globulin as an effective component are used as an immunomodulating agent, a suppressive agent for eosinophilia, and as an antiinflammatory agent. The immunomodulating action is unexpectedly different from the action of conventional immunosuppressive agents. Accordingly, the compositions are useful as a pharmaceutical agent for the therapy of diseases associated with an abnormal immune system such as chronic articular rheumatism, systemic lupus erythematosus, multiple sclerosis, etc. and various types of immunodeficiency syndromes. In addition, the pharmaceutical compositions exhibit suppressive action upon hypereosinophilicity. They may be used as a therapeutic agent for infectious diseases, parasitic diseases, respiratory diseases, autoimmune diseases and eosinophilia caused by malignant tumors. The compositions are excellent antiinflammatory agents.

REFERENCES:
patent: 4704273 (1987-11-01), McMichael
patent: 4705685 (1987-11-01), McMichael
patent: 4705687 (1987-11-01), Lau
patent: 5354848 (1994-10-01), Faligiani et al.
patent: 5622970 (1997-04-01), Armistead et al.
patent: 5639758 (1997-06-01), Sharpe et al.
Curtis et al., Biology, Fifth Edition, Worth Publication; (New York) 1989 pp. 835-836.
M. Naiki et al., "Neurotropin Inhibits Experimental Allergic Encephalomyelitis (EAE) in Lewis Rats", Int. J. Immunopharmac., 13(2/3), 235-243 (1991).
"Drug Evaluations Annual 1995", American Medical Association, pp. 438-445 (1995).
Goodin, "The use of immunosuppressive agents in the treatment of multiple sclerosis: A critical review", Neurology, vol. 41, pp. 980-985 (1991).
Higashiguchi, et al., Chemical Abstracts 112:111828b, 1990.
Getlik, et al., Chemical Abstracts 67, #5, 20482v, 1967.
Volokhovskaya, et al., Chemical Abstracts, 115:21847q, 1991.
Yoshii, et al., "Inhibitory Effect of Histamine-Added Mouse .gamma.-Globulin On Eosinophil Accumulation Induced By Allergen In Balb/c Mice", Japanese Journal of Allergology, 44:567-570 (1995).
Yoshii, et al., "A New Assay System Detecting Antibody Production And Delayed-Type Hypersensitivity Responses To Trinitrophenyl Hapten In An Individual Mouse", Int. J. Immunopharmac., vol. 18, No. 1, pp. 31-36, 1996.
Fujiwara, et al., "Sandwich enzyme immunoassay of tumor-associated antigen sialosylated Lewis using .beta.-D-galactosidase coupled to a monoclonal antibody of IgM isotype", Journal of Immunological Methods, 112, pp. 77-83, 1988.
Burnham, "Polymers for delivering peptides and proteins", Am J Hosp Pharm, vol. 51, pp. 210-218, Jan. 15, 1994.
Wood, et al., Biochemistry A Problems Approach, 2nd edition, pp. 155-156, 1981.
Naiki, et al., 9th International Congress of Immunology, p. 183, abstract 1084, Jul. 23-29, 1995.
Kaneko, et al., "Role of Interleukin-5 in Local Accumulation of Eosinophils in Mouse Allergic Peritonitis," Int. Arch Allergy Appl Immunol., 1991; 96:41-45.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Immunomodulating and antiinflammatory agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunomodulating and antiinflammatory agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunomodulating and antiinflammatory agent will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1879217

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.