Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1994-08-08
1998-07-14
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241331, 514 2, 514 21, 514826, 514885, 514887, A61K 3514, A61K 3516
Patent
active
057800260
ABSTRACT:
In the present invention, pharmaceutical compositions containing a histamine-added gamma-globulin as an effective component are used as an immunomodulating agent, a suppressive agent for eosinophilia, and as an antiinflammatory agent. The immunomodulating action is unexpectedly different from the action of conventional immunosuppressive agents. Accordingly, the compositions are useful as a pharmaceutical agent for the therapy of diseases associated with an abnormal immune system such as chronic articular rheumatism, systemic lupus erythematosus, multiple sclerosis, etc. and various types of immunodeficiency syndromes. In addition, the pharmaceutical compositions exhibit suppressive action upon hypereosinophilicity. They may be used as a therapeutic agent for infectious diseases, parasitic diseases, respiratory diseases, autoimmune diseases and eosinophilia caused by malignant tumors. The compositions are excellent antiinflammatory agents.
REFERENCES:
patent: 4704273 (1987-11-01), McMichael
patent: 4705685 (1987-11-01), McMichael
patent: 4705687 (1987-11-01), Lau
patent: 5354848 (1994-10-01), Faligiani et al.
patent: 5622970 (1997-04-01), Armistead et al.
patent: 5639758 (1997-06-01), Sharpe et al.
Curtis et al., Biology, Fifth Edition, Worth Publication; (New York) 1989 pp. 835-836.
M. Naiki et al., "Neurotropin Inhibits Experimental Allergic Encephalomyelitis (EAE) in Lewis Rats", Int. J. Immunopharmac., 13(2/3), 235-243 (1991).
"Drug Evaluations Annual 1995", American Medical Association, pp. 438-445 (1995).
Goodin, "The use of immunosuppressive agents in the treatment of multiple sclerosis: A critical review", Neurology, vol. 41, pp. 980-985 (1991).
Higashiguchi, et al., Chemical Abstracts 112:111828b, 1990.
Getlik, et al., Chemical Abstracts 67, #5, 20482v, 1967.
Volokhovskaya, et al., Chemical Abstracts, 115:21847q, 1991.
Yoshii, et al., "Inhibitory Effect of Histamine-Added Mouse .gamma.-Globulin On Eosinophil Accumulation Induced By Allergen In Balb/c Mice", Japanese Journal of Allergology, 44:567-570 (1995).
Yoshii, et al., "A New Assay System Detecting Antibody Production And Delayed-Type Hypersensitivity Responses To Trinitrophenyl Hapten In An Individual Mouse", Int. J. Immunopharmac., vol. 18, No. 1, pp. 31-36, 1996.
Fujiwara, et al., "Sandwich enzyme immunoassay of tumor-associated antigen sialosylated Lewis using .beta.-D-galactosidase coupled to a monoclonal antibody of IgM isotype", Journal of Immunological Methods, 112, pp. 77-83, 1988.
Burnham, "Polymers for delivering peptides and proteins", Am J Hosp Pharm, vol. 51, pp. 210-218, Jan. 15, 1994.
Wood, et al., Biochemistry A Problems Approach, 2nd edition, pp. 155-156, 1981.
Naiki, et al., 9th International Congress of Immunology, p. 183, abstract 1084, Jul. 23-29, 1995.
Kaneko, et al., "Role of Interleukin-5 in Local Accumulation of Eosinophils in Mouse Allergic Peritonitis," Int. Arch Allergy Appl Immunol., 1991; 96:41-45.
Fukata Yuriko
Yoshii Haruo
Nippon Zoki Pharmaceutical Co. Ltd.
O'Sullivan Peter
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