Immunologically active synthetic peptides useful for preparing a

Details Immunologically active synthetic peptides useful for preparing a Immunologically active synthetic peptides useful for preparing a

1988-11-28

1990-09-11

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

424 88, 514 12, 514 13, 514 14, 514 15, 514 16, 530325, 530326, 530327, 530328, C07K 710

Patent

active

049564498

ABSTRACT:
Synthetic peptides consisting of at least two consecutive repeating units of the sequence (Ala-Asn-Asn-Pro) are powerful immunogens in experimental animals.
The antibodies which form recognize both said synthetic peptides and the immunodominant epitope of the circumsporozoitic peptide of Plasmodium falciparum.
Said peptides, obtainable in pure form, are particularly useful for preparing antimalarial vaccines and diagnostic kits for the determination of malarial affections.

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Proceedings of the National Academy of Sciences of the United States America, vol. 84, No. 13, Jul. 1987, pp. 4470-4474.
Proceedings of the National Academy of Sciences of the United States of America, vol. 85, No. 4, Feb. 1988, pp. 1199-1203.

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