Immunologically active polypeptides useful for the preparation o

Details Immunologically active polypeptides useful for the preparation o Immunologically active polypeptides useful for the preparation o

1987-12-03

1989-06-27

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

424 88, 435 7, C07C10352, A61K 3900

Patent

active

048431460

ABSTRACT:
Immunologically active polypeptides constituted, towards the N-terminated end, by an Asn-Val-Asp-Pro-Asn-Ala-Asn-Pro sequence repeated three times and, towards the C-terminated end, by at least three quadruplets with an Asn-Ala-Asn-Pro sequence, linked with each other by means of an amidic bond between the end proline of the first sequence, and the initial asparagine of the first quadruplet.
Said polypeptides reproduce nearly exactly the sequential structure of the circumsporozoite protein of P. falciparum, and are useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies in clinical samples of malariated persons.

REFERENCES:
Dame, Science, 225, 593 (1984).
Gibson, Proc. Natl. Acad. Sci., USA, 83, 5649 (1986).
Del Giudice, The Journal of Immunology, 137, 2952 (1986).

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