Immunological tolerance-inducing agent

Details Immunological tolerance-inducing agent Immunological tolerance-inducing agent

1997-06-27

2000-11-28

Swartz, Rodney P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242411, 4242751, 4242821, 424810, 514885, 530868, A61K 3902, A61K 39108, A61K 39106

Patent

active

061532037

ABSTRACT:
An agent comprising a mucosa-binding molecule linked to a specific microbial antigen is disclosed. Further, a method of inducing immunological tolerance in an individual against a specific microbial antigen, including hapten, which causes an unwanted immune response in said individual, comprising administration by a mucosal route of an immunologically effective amount of an immunological tolerance-inducing agent of the invention to said individual, is described.

REFERENCES:
Avrameas, S. et al., Immuno-chemistry 6:53, 1969.
Bierme, S.J. et al., Lancet, 1:605-606, 1979.
Carlsson J., et al., Biochem. J. 173:723-737, 1978.
Chase, M.W., Proc. Soc. Exp. Biol. 61:257-259, 1946.
Cumber, J.A., et al. Methods in Enzymology 112:207-224, 1985.
Czerkinsky, C., et al., Infect. Immun.57: 1072-1077, 1989.
de Aizpurua, H.J., et al., J. Exp. Med. 167:440-451, 1988.
Elson, C.O. et al., J. Immunol. 132:2736, 1984.
Elson, C.O. et al., J. Immunol. 133:2892, 1984.
Gordon, R.D. et al., Proc. Natl. Acad. Sci. (USA) 84:308-312, 1987.
Hansson, D.G. et al., J. Immunol. 122:2261, 1979.
Hirst T.R., et al., Proc. Natl. Acad. Sci. USA, 81:7752-7756, 1984.
Joseph, K.C. et al., Proc. Natl. Acad. Sci. USA 75:2815-2819, 1978.
Lehner, T. et al., Science 258(5036):1365-1369, 1992.
Martinon, F. et al., Eur. J. Immunol. 23:1719-1722, 1993.
Mattingly, J. et al., J. Immunol. 121:1878, 1978.
McKenzie, S.J. et al., J. Immunol. 133:1818-1824, 1984.
Nabel, G.J. et al., Trends in Biochemistry vol. 11, No. 5, pp. 211-215, 1993.
Nedrud, J.G. et al., J. Immunol. 139:3484-3492, 1987.
Robinson, H.L. et al., Vaccine 11:957-960, 1993.
Rohrbaugh, M.L. et al, N. Y. Acad. Sci. 685:697-712, 1993.
Sanchez, J. et al., Proc. Natl. Acad. Sci. USA 86:481-485, 1989.
Thomas H.C. et al., Immunology 27:631-639, 1974.
Walden, P. et al., J. Mol. Cell Immunol. 2:191-197, 1986.
Weinstock, JV et al., J. Immunol. 135:560-563, 1985.
Wells, H., J. Infect. Dis. 9:147, 1911.

Affiliated with

Also associated with

Rating

Immunological tolerance-inducing agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunological tolerance-inducing agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunological tolerance-inducing agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1722194